I had one on my 75g reef, tho i only used it for chemical filtration. I ran it without any foam pads. I had no sump /wet-dry or anything like that, so i used the fluval for using a bag of carbon and/or purigen... and other than the water flow, it was used for nothing more.
If you get/use one, i'd recommend using it the same way. You really don't want to use the mechanical filtration in it , since it will only work against the tank in short order.
And you you DO get one, pick up a extra impeller cover b4 you do the any cleaning of the impeller down the road. They seem to get brittle over time, and you don't want to be stuck w/ a broken Fluval and not have a spare cover,,,trust me,,by about the 2nd-3rd time over the years, i learned to have a spare at the ready , just for when the locking tabs break off when you either take off the cover or re-install it after removing a impeller to clean it.And they WILL break!