I don't know about drilled and tapped. I think the thin wall would not hold threads well enough. I would rather us a UniSeal in the worst case, or better yet glue a fitting to the side that gives good support and leak protection.
This might be something that isn't worth building like VWD was illuding to. There is allot of R&D that goes into the right amount of air for neck height, and size, the right flowthrough, water level, skimmer cup edge height etc. You could fiddle and get it right, but it's not as simple as many other DIY projects in this hobby.
Whiskey