I've been using bio clean for a while and I've noticed a difference in the amount of algae and the nitrate levels in the system. I first used Prodibio when my tank cracked. I needed to hold a bunch of coral and fish in bins and temporary tank. I saw no spike and no loss of life (well, one fish did jump). My wife recently started using the Prodibio nano kit for her tank. She saw a drastic improvement in her system. She had 2 polyps that had been in the system for a long without multiplying. Within, I think, a month of dosing Prodibio they had quadrupled. It's not a magic solution that fixes everything, but I have been pleased with the results.