Many different phylosophies here to nail it down. There are so many variables it makes my head spin
I like a bare bottom theory, but hate the looks of it! SO I use about 2" of sand and clean it regularly. I suck diatris out sometimes, somtimes I suck sand out. Sometimes I use a cannister filter to suck stuff out. Sometimes I suck a bunch of sand and diatris, poor the crud out and then put the sand back in the tank. Somtime, I pull a bunch out and replace it. I never do the whole tank at once and try to break the tank into three sections. For a smaller tank, I would probably do two.
It's extra work doing things this way, but I like a natural look and I like sand critters
I keep thinking of a couple tanks I know that used sand and quality flow principals and are very healthy. One of my favorite tanks of all time has a DSB and is going on it's 11th year. I wish I knew what he was doing right
