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Well this becomes a flow ratio problem. The book "Aquatic Systems Engineering: Devices and How They Work" by P.R. Escobal., has a great couple of chapters regarding this subject and also has a table of UV kill rate doses for spacific organisms on Pages 33 and 48.
By adjusting your flow rates you will intern effect the time it will take to "sterilize" your tank to any given decimal point of purity. (Since you can NEVER really TOTALLY sterilize your tank.) I suggest looking up the reference to see what you are willing to compramise with regarding your flow rates. You should get better kill rates at lower flow but it will take much longer to get the purity desired overall. I hope this helps.
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ReefDoctor
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