What kind of skimmer you got? After two years with as many as 6 tanks at a time, I've decided that the biggest problems (mistakes) I've had are too high a level of organics in the water. Water changes and high performance skimming have mostly cured me of everything.
I've got two plates and they've been amazingly resilient to my blundering. I have noticed that they do not extend their tentacles when the organics are too high. (I may try to develop an anal retentive attitude about it. Let's see,
Ron Shimek thinks its all about worms, Spanky thinks all the problems of the world can be solved by removing phosphates, and I think every tank would be beautiful if you maintained low levels of organics. See, the deal is I just bought a TOC (total organ carbon) analyzer and if you'll send me a sample of your tank water, for a "nominal fee" I'll tell you what you need to do to correct it!)