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what are you intending to do by drilling? Install a sump? An overflow box limits how much water can flow out of the tank, and is definitely the solution if you're trying to add a sump. If you just stick a bulkhead in place, there's nothing to keep water from draining out to where the bulkhead is (if it's in the bottom of the tank, you're really asking for trouble).
regarding filter floss, I would not recommend sticking it in the overflow box. anything that can trap wastes is a cause for concern, and unless you plan on cleaning it out a couple times a week it will probably cause more harm than good.
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