Yes, I would siphon the substrate with every water change. The more gunk/detritus you can remove before getting broken down the better.
When replace evaporation for RO water. No buffers etc. should be needed.
Np reconstituting type buffers need to be added if that's what your referring to when mixing salt water. Most salts are designed to be mixed with RO/DI water.
However, for me when mixing fresh saltwater, I do add some magnesium and Ca additives to my
freshly mixed salt water to bring them up to the levels that I maintain in the main system. I use IO and/or ReefCrystals. Both of which need additives to get to the levels I like them to be. ALK typically doesn't need adjusted as usually tests out at or near 10dkh.
% per water change is totally up to you. General consensus is usually 10-20% but nothing set in stone and could even be 50% or more as long as your newly mixed water matches pretty closely in temp,PH,CA,ALK,Mg as your show tank.